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Article

Structural basis of odorant recognition by a human odorant receptor.

Nature - 1 Mar 2023

Billesbølle Christian B, de March Claire A, van der Velden Wijnand J C, Ma Ning, Tewari Jeevan, Del Torrent Claudia Llinas, Li Linus, Faust Bryan, Vaidehi Nagarajan, Matsunami Hiroaki, Manglik Aashish

Abstract excerpt

Our sense of smell enables us to navigate a vast space of chemically diverse odour molecules. This task is accomplished by the combinatorial activation of approximately 400 odorant G protein-coupled receptors encoded in the human genome1-3. How odorants are recognized by odorant receptors remains unclear. Here we provide mechanistic insight into how an odorant binds to a human odorant receptor. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36922591
DOI: 10.1038/s41586-023-05798-y
PMCID: PMC10580732

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