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Article

Structural basis for multivitamin recognition and transport by human SMVT.

Nature communications - 27 Jun 2026

Zhen Qiuxin, Wang Mingshuai, Zhang Zhe

Abstract excerpt

The human sodium-dependent multivitamin transporter (SMVT, SLC5A6) mediates cellular uptake of essential metabolic cofactors, including biotin, pantothenate, and lipoate. Its dysfunction is associated with neurological disorders, metabolic abnormalities, and cancer. However, the molecular mechanism underlying its multi-substrate transport has remained elusive. Here, we present cryo-electron microscopy structures...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42364996
DOI: 10.1038/s41467-026-74948-3
PMCID: PMC13454448

Genes

SLC5A6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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