Unsaturated bond recognition leads to biased signal in a fatty acid receptor.

doi:10.1126/science.add6220

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Article

Unsaturated bond recognition leads to biased signal in a fatty acid receptor.

Science (New York, N.Y.) - 7 Apr 2023

Mao Chunyou, Xiao Peng, Tao Xiao-Na, Qin Jiao, He Qing-Tao, Zhang Chao, Guo Sheng-Chao, Du Ya-Qin, Chen Li-Nan, Shen Dan-Dan, Yang Zhi-Shuai, Zhang Han-Qiong, Huang Shen-Ming, He Yong-Hao, Cheng Jie, Zhong Ya-Ni, Shang Pan, Chen Jun, Zhang Dao-Lai, Wang Qian-Lang, Liu Mei-Xia, Li Guo-Yu, Guo Yongyuan, Xu H Eric, Wang Chuanxin, Zhang Cheng, Feng Shiqing, Yu Xiao, Zhang Yan, Sun Jin-Peng

Abstract excerpt

Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through engagement with more than 40G protein-coupled receptors. Searching for receptors to sense beneficial omega-3 FAs of fish oil enabled the identification of GPR120, which is involved in a spectrum of metabolic diseases. Here, we report six cryo-electron microscopy structures of GPR120 in complex with FA hormones or TUG891...

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PMID: 36862765
DOI: 10.1126/science.add6220

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