Back to search

Article

Structural and biochemical insight into allosteric regulation of the human 2-aminoadipic semialdehyde synthase, a bifunctional enzyme involved in lysine catabolism

2026-05-04

Abstract excerpt

<title>Abstract</title> <p>Multiple clinically significant inborn errors of metabolism occur in the lysine degradation, even so the regulation of this biochemical pathway remains understudied. The initial rate-limiting step of lysine catabolism is catalyzed by the bifunctional enzyme 2-aminoadipic semialdehyde synthase (AASS). Therefore, understanding the regulation of AASS activity in normal and disease states w...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
841a792a-d654-53fd-96aa-2d556725099a
DOI
10.21203/rs.3.rs-9509715/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Structural and biochemical insight into allosteric regulation of the human 2-aminoadipic semialdehyde synthase, a bifunctional enzyme involved in lysine catabolismDOI 10.21203/rs.3.rs-9509715/v1
Structural and biochemical insight into allosteric regulation of the human 2-aminoadipic semialdehyde synthase, a bifunctional enzyme involved in lysine catabolismSemantic proximity
Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1Semantic proximity
Insights into Aldehyde Dehydrogenase Enzymes: A Structural PerspectiveSemantic proximity
Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism.Semantic proximity
Human ASPDH is a 2-aminomuconate reductase that produces L-2-aminohex-3-enedioic acid in tryptophan catabolismSemantic proximity
Succinic semialdehyde dehydrogenase deficiency: exploring the relationship between ALDH5A1 variants and molecular effect on SSADH.Semantic proximity
Comprehensive exploration of isocitrate dehydrogenase (IDH) mutations: Tumorigenesis, drug discovery, and covalent inhibitor advances.Semantic proximity
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanismsSemantic proximity
Structure-function analyses of the G729R 2-oxoadipate dehydrogenase genetic variant associated with a disorder of l-lysine metabolism.Semantic proximity
Pan-Cancer Expression Analysis of the Aminoadipate-semialdehyde synthase (AASS) Gene: Insights into its Potential Role in Oncogenic Metabolic ReprogrammingSemantic proximity
Active site remodeling in tumor-relevant IDH1 mutants drives distinct kinetic features and potential resistance mechanismsSemantic proximity
Protein post-translational modification by lysine succinylation: Biochemistry, biological implications, and therapeutic opportunitiesSemantic proximity
Select a neighboring publication to make it the new centre.