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Article

Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2.

Nature communications - 29 Apr 2024

Hu Wenxin, Song Alex, Zheng Hongjin

Abstract excerpt

SLC26A2 is a vital solute carrier responsible for transporting essential nutritional ions, including sulfate, within the human body. Pathogenic mutations within SLC26A2 give rise to a spectrum of human diseases, ranging from lethal to mild symptoms. The molecular details regarding the versatile substrate-transporter interactions and the impact of pathogenic mutations on SLC26A2 transporter function remain...

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Identifiers

PMID: 38684689
DOI: 10.1038/s41467-024-48028-3
PMCID: PMC11059360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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