Article

White matter hyperintensity genetic risk factor <i>TRIM47</i> regulates autophagy in brain endothelial cells

2023-12-19

Abstract excerpt

<h4>ABSTRACT</h4> White matter hyperintensity (WMH) is strongly correlated with age-related dementia and hypertension, but its pathogenesis remains obscure. GWAS identified TRIM47 at 17q25 locus as a top genetic risk factor for WMH formation. TRIM family is a class of E3 ubiquitin ligase with pivotal functions in autophagy, which is critical for brain endothelial cell (ECs) remodeling during hypertension. We hypo...

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Literature Corpus work: 8570bd58-6cdd-5ae8-a4a2-cfc588774ca9
DOI: 10.1101/2023.12.18.566359

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