Article

Multiomics Profiling Supports Cathepsin B as a Protective Factor in Cerebral Small Vessel Disease

2026-04-19

Abstract excerpt

<title>Abstract</title> <p>White matter hyperintensities (WMH) are a common brain MRI marker of cerebral small vessel disease and a major risk factor for stroke and dementia, yet the molecular mechanisms governing lesion formation remain incompletely understood. Here, we combined large-scale proteomic and genomic data with tissue- and single-nucleus transcriptomic validation to identify circulating proteins that...

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Literature Corpus work: eee4b7cd-8cf6-579f-b3ca-cdfeb4b4dcd4
DOI: 10.21203/rs.3.rs-9013964/v1

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