Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic evidence links hypertension to accelerated brain aging.

Biogerontology - 16 Jul 2026

Zhu Xiaoyang, Zhang Shuaiqi, Liu Zhiyuan, Nie Ben

Abstract excerpt

Hypertension affects one-third of adults and is a major comorbidity of neurocognitive disorders. The causal relationship, shared genetic architecture, and upstream mechanisms linking hypertension to brain aging remain unclear. Hypertension GWAS datasets from MVP and FinnGen R12 were meta-analyzed as the exposure, and a European-ancestry brain age gap (BAG) GWAS derived from the UK Biobank and LIFE-Adult cohorts...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Brain
Share to MVP gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Hypertension

Source

Identifiers

PMID: 42461423
DOI: 10.1007/s10522-026-10475-4

Genes

TRIM47
CA1
MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence links hypertension to accelerated brain aging.PMID 42461423Read ↗

Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK BiobankSemantic proximity Read ↗

Genome-wide analysis of brain age identifies 25 associated loci and unveils relationships with mental and physical healthSemantic proximity Read ↗

Elevated blood pressure accelerates white matter brain aging among late middle-aged women: a Mendelian Randomization study in the UK BiobankSemantic proximity Read ↗

The genetic landscape of brain ageingSemantic proximity Read ↗

The Genetic Architecture of Multimodal Human Brain AgeSemantic proximity Read ↗

Genome-wide association analysis of hypertension and epigenetic aging reveals shared genetic architecture and identifies novel risk loci.Semantic proximity Read ↗

Genetics of age-related white matter lesions from linkage to genome wide association studies.Semantic proximity Read ↗

Novel and Known Genetic Players in Hypertension: From Gene Expression to Striking InsightsSemantic proximity Read ↗

Genes from a translational analysis support a multifactorial nature of white matter hyperintensities.Semantic proximity Read ↗

Cerebral small vessel disease genomics and its implications across the lifespanSemantic proximity Read ↗

An Academic Clinician's Road Map to Hypertension Genomics: Recent Advances and Future Directions MMXX.Semantic proximity Read ↗

Multi-ancestry transcriptome-wide association studies of cognitive function, white matter hyperintensity, and Alzheimer’s diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.