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White matter hyperintensity genetic risk factor TRIM47 regulates autophagy in brain endothelial cells

27 Sept 2024

Abstract excerpt

White matter hyperintensity (WMH) is strongly correlated with age-related dementia and hypertension, but its pathogenesis remains obscure. Genome-wide association studies identified TRIM47 at the 17q25 locus as a top genetic risk factor for WMH formation. TRIM family is a class of E3 ubiquitin ligase with pivotal functions in autophagy, which is critical for brain endothelial cell (ECs) remodeling during...

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PMID: 39331575
DOI: 10.1096/fj.202400689rr

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