Article

Cerebral Small Vessel Disease genetic determinant TRIM47 controls brain homeostasis <i>via</i> the NRF2 antioxidant system

2024-10-12

Abstract excerpt

Cerebral small vessel disease (cSVD) is a leading cause of stroke, cognitive decline and dementia, for which no specific mechanism-based treatments are available to date. Genome-wide and whole-exome association studies previously identified robust associations of common variants at chr17q25 with cSVD features on magnetic resonance imaging, with converging bioinformatic and experimental data for a causal involvemen...

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Literature Corpus work: 40fe7e89-8980-563d-bfcc-832e098546b1
DOI: 10.1101/2024.10.08.616723

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