Article

Sox17 Protects Human Brain Microvascular Endothelial Cells from AngII-induced Injury by Regulating Autophagy and Apoptosis

2023-05-11

Abstract excerpt

Intracranial aneurysm (IA), is a localized dilation of the intracranial arteries, the rupture of which is catastrophic. Hypertension is major IA risk factor that mediates endothelial cell damage. Sox17 is highly expressed in intracranial vascular endothelial cells, and GWAS studies indicate that its genetic alteration is one of the major genetic risk factors for IA. Vascular endothelial cell injury plays a vital r...

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Literature Corpus work: b09e26ef-33a1-5bf1-b54a-aea0dc0ff953
DOI: 10.21203/rs.3.rs-2907816/v1

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