Article

Endothelial TRIM47 regulates blood-brain barrier integrity and cognition via the KEAP1/NRF2 signalling pathway

2025-06-02

Abstract excerpt

<title>Abstract</title> <p>Cerebral small vessel disease (cSVD) is a leading cause of stroke, cognitive decline and dementia, for which no specific mechanism-based treatments are currently available. Previous genomic studies identified associations of common variants at chr17q25 with cSVD features, with converging evidence for a causal involvement of TRIM47, an ubiquitin ligase enriched in brain endothelial cells...

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Literature Corpus work: 85bade73-a333-5063-9750-12998e3d9e8e
DOI: 10.21203/rs.3.rs-6579058/v1

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