Article

Pathway Analysis within Multiple Human Ancestries Reveals Novel Signals for Epistasis in Complex Traits

2020-09-25

Abstract excerpt

Genome-wide association (GWA) studies have identified thousands of significant genetic associations in humans across a number of complex traits. However, the majority of these studies focus on linear additive relationships between genotypic and phenotypic variation. Epistasis, or non-additive genetic interactions, has been identified as a major driver of both complex trait architecture and evolution in multiple mo...

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Literature Corpus work: 2e424200-4918-5876-a43b-d55b462a0b3f
DOI: 10.1101/2020.09.24.312421

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