Article

Evidence of epistasis in regions of long-range linkage disequilibrium across five complex diseases in the UK Biobank and eMERGE datasets

2022-10-21

Abstract excerpt

Leveraging linkage disequilibrium (LD) patterns as representative of population substructure enables the discovery of additive association signals in genome-wide association studies (GWAS). Standard GWAS are well-powered to interrogate additive models; however, new approaches are required to investigate other modes of inheritance such as dominance and epistasis. Epistasis, or non-additive interaction between genes...

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Literature Corpus work: 5338044e-34d6-51d6-bc73-fcc705b5b3a0
DOI: 10.1101/2022.10.19.22280888

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