Article

Genomic and epigenomic insights into purkinje and granule neurons in Alzheimer’s disease and related dementia using single-nucleus multiome analysis

2025-04-01

Abstract excerpt

<title>Abstract</title> Although the human cerebellum is known to be neuropathologically impaired in Alzheimer’s disease (AD) and AD-related dementias (ADRD), the cell type-specific transcriptional and epigenomic changes that contribute to this pathology are not well understood. Here, we report single-nucleus multiome (snRNA-seq and snATAC-seq) analysis of 103,861 nuclei isolated from both cerebellum and front...

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Literature Corpus work: 12c3839b-b1a7-5524-a953-370eecde4258
DOI: 10.21203/rs.3.rs-6264481/v1

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