Article

A Manifold-Based Measure of Transcriptional Entropy for Quantifying Aging in Single Cells

2026-01-24

Abstract excerpt

Characterizing cellular aging is essential for understanding age-related diseases. While tissue-level studies reveal broad age-associated changes, they often reflect compositional shifts rather than cell-level reprogramming. The cellular damage hypothesis posits that aging involves the accumulation of DNA, chromatin, and other damage across molecular layers, increasing transcriptional entropy. Existing supervised...

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Identifiers and source

Literature Corpus work: 8526b068-47a6-5bd0-a496-4099ab3560f1
DOI: 10.64898/2026.01.24.701460

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