Article

Characterizing Cellular Heterogeneity and Transcriptomic Features of Senotype Using Deep Graph Representation Learning

2025-07-04

Abstract excerpt

<h4>ABSTRACT</h4> Cellular senescence is a primordial driver of tissue and organ aging, and the accumulation of senescent cells (SnCs) has been implicated in numerous age-related diseases. A major barrier to studying senescence is the rarity and heterogeneity of SnCs, which are not a uniform population but instead comprise diverse senotypes shaped by cell-of-origin and microenvironmental context. Such heterogenei...

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Literature Corpus work: db0991b8-3dcd-5ad2-a723-fe05be26b9d1
DOI: 10.1101/2025.07.01.662364

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