Article
Age-related loss of gene-to-gene transcriptional coordination among single cells.
Nature metabolism - 1 Nov 2020
Levy Orr, Amit Guy, Vaknin Dana, Snir Tom, Efroni Sol, Castaldi Peter, Liu Yang-Yu, Cohen Haim Y, Bashan Amir
Abstract excerpt
A long-standing model holds that stochastic aberrations of transcriptional regulation play a key role in the process of ageing. While transcriptional dysregulation is observed in many cell types in the form of increased cell-to-cell variability, its generality to all cell types remains doubted. Here, we propose a new approach for analysing transcriptional regulation in single-cell RNA sequencing data by focusing...
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