Article

Aging causes changes in transcriptional noise across a diverse set of cell types

2022-06-26

Abstract excerpt

Aging and its associated diseases result from complex changes in cell state which can be examined with single-cell transcriptomic approaches. We analyzed gene expression noise, a measure of cellular heterogeneity, across age and many cell types and tissues using the single cell atlas Tabula Muris Senis , and characterized the noise properties of most coding genes. We developed a quantitative, well-calibrated stat...

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Literature Corpus work: 1112f92f-68a2-595f-a353-54277749bcfd
DOI: 10.1101/2022.06.23.497402

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