Article

Causally measuring aging and rejuvenation through transcriptomic damage

2026-06-29

Abstract excerpt

<h4>ABSTRACT</h4> Aging is caused, fully in large part, by the progressive accumulation of damage, yet quantifying age-related damage across tissues and conditions remains a challenge. Here, we present a computational framework to quantify damage from standard RNA-sequencing data. It captures four classes of aberrant transcript structures, including premature termination upon intron retention, domain-disrupting s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 556f3b2f-42a5-5ddb-8d9b-19de27e7cf13
DOI: 10.64898/2026.06.26.734659

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Causally measuring aging and rejuvenation through transcriptomic damageDOI 10.64898/2026.06.26.734659Read

Transcriptomic Hallmarks of Mortality Reveal Universal and Specific Mechanisms of Aging, Chronic Disease, and RejuvenationSemantic proximity Read

Direct RNA sequencing reveals multi-layered regulation of the aging transcriptomeSemantic proximity Read

Pasta, a versatile transcriptomic clock, maps the chemical and genetic determinants of aging and rejuvenationSemantic proximity Read

Cell-specific RNA isoform remodeling in the aging mouse brainSemantic proximity Read

Multi-tissue spatial transcriptomics reveals biological age hotspots in mouse and human agingSemantic proximity Read

Aging is associated with a systemic length-driven transcriptome imbalanceSemantic proximity Read

A transcriptome-based single-cell biological age model and resource for tissue-specific aging measures.Semantic proximity Read

Mammalian aging involves genome-wide splicing degeneration leading to functional declineSemantic proximity Read

Transcriptomic age prediction using mixture-of-experts models reveals tissue-specific aging signatures in large-scale human RNA-sequencing dataSemantic proximity Read

SkeletAge: Transcriptomics-based Aging Clock Identifies 26 New Targets in Skeletal Muscle AgingSemantic proximity Read

Age- or lifestyle-induced accumulation of genotoxicity is associated with a generalized shutdown of long gene transcriptionSemantic proximity Read

ORANGE: A Machine Learning Approach for Modeling Tissue-Specific Aging from Transcriptomic DataSemantic proximity Read