Article

Cell-attribute aware community detection improves differential abundance testing from single-cell RNA-Seq data

2023-04-29

Abstract excerpt

Variations of cell-type proportions within tissues could be informative of biological aging and disease risk. Single-cell RNA-sequencing offers the opportunity to detect such differential abundance (DA) patterns, yet this task can be statistically challenging due to the noise in single-cell data, inter-sample variability and because DA patterns are often of small effect size. Here we present a DA-testing paradigm...

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Literature Corpus work: bf1ad809-5087-5d55-8be0-4152a92c4c18
DOI: 10.1101/2023.04.28.538653

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