Article

Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence <i>in vitro</i> and in the aging human hippocampus

2021-04-28

Abstract excerpt

<h4>ABSTRACT</h4> The increase in senescent cells in tissues, including the brain, is a general feature of normal aging and age-related pathologies. Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes. Astrocytes undergo senescence in vitro and in age-associated neurodegenerative diseases, but little is known about whether this process also occurs...

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Literature Corpus work: 84fac08f-6e4b-516c-ab0f-cf6099f47ea1
DOI: 10.1101/2021.04.27.440997

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