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Senescent astrocytic deposits drive cognitive decline by disrupting tripartite synapse in the aging brain

2025-11-02

Abstract excerpt

Brain aging involves synapse decline, with astrocytes playing a key role in synapse homeostasis. However, the impact of astrocyte senescence on synaptic dysfunction and cognitive decline remains unclear. Here, we identified a hallmark of aging astrocytes—Senescent Astrocytic Deposits (SAD) observed at aged rodents, macaques, and human hippocampal astrocytic processes —that is associated with tripartite synapse dys...

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Identifiers and source

Literature Corpus work
3b999e68-85fe-5185-a57e-c2bd2addc109
DOI
10.1101/2025.10.31.685958
Open publication

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Senescent astrocytic deposits drive cognitive decline by disrupting tripartite synapse in the aging brainDOI 10.1101/2025.10.31.685958
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