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Article

SerpinA3N Regulates the Secretory Phenotype of Mouse Senescent Astrocytes Contributing to Neurodegeneration.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Apr 2024

Han Xiaojuan, Lei Qing, Liu Huanhuan, Zhang Tianying, Gou Xingchun

Abstract excerpt

Senescent astrocyte accumulation in the brain during normal aging is a driver of age-related neurodegenerative diseases such as Alzheimer's disease. However, the molecular events underlying astrocyte senescence in Alzheimer's disease are not fully understood. In this study, we demonstrated that senescent astrocytes display a secretory phenotype known as the senescence-associated secretory phenotype (SASP), which...

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PMID: 38175667
DOI: 10.1093/gerona/glad278

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