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Article

Lamin B1 loss is a senescence-associated biomarker

12 Apr 2012

Abstract excerpt

Cellular senescence is a potent tumor-suppressive mechanism that arrests cell proliferation and has been linked to aging. However, studies of senescence have been impeded by the lack of simple, exclusive biomarkers of the senescent state. Senescent cells develop characteristic morphological changes, which include enlarged and often irregular nuclei and chromatin reorganization. Because alterations to the nuclear...

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PMID: 22496421
DOI: 10.1091/mbc.e11-10-0884

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