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Article

Changes in the Transcriptome of Human Astrocytes Accompanying Oxidative Stress-Induced Senescence

30 Aug 2016

Abstract excerpt

Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression, and typically demonstrate altered, pro-inflammatory profiles. Astrocyte senescence has been implicated in neurodegenerative disease, and to better understand...

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Share to Neuroinflammation and Neurodegeneration Mechanisms
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PMID: 27630559
DOI: 10.3389/fnagi.2016.00208

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