Article

Single cell Correlation Analysis (SCA): Identifying self-renewing subpopulation of human acute myeloid leukemia stem cells using single cell RNA sequencing analysis

2026-03-02

Abstract excerpt

Leukemia stem cells (LSCs), a rare and self-renewing subpopulation, drive Acute myeloid leukemia (AML) relapse and therapy resistance. While single-cell gene expression profiling (scGEP) offers high-resolution insights into LSC biology, existing computational tools rely on relative and arbitrary similarity metrics. This limits their ability to definitively identify true biological cell identities or compare rare c...

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Literature Corpus work: 84eec5b6-8cb7-5c57-9d06-6f37645d3e52
DOI: 10.64898/2026.02.27.708585

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