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Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication

5 Jan 2021

Abstract excerpt

Single-cell RNA sequencing provides exciting opportunities to unbiasedly study hematopoiesis. However, our understanding of leukemogenesis was limited due to the high individual differences. Integrated analyses of hematopoiesis and leukemogenesis potentially provides new insights. Here we analyzed ~200,000 single-cell transcriptomes of bone marrow mononuclear cells (BMMCs) and its subsets from 23 clinical...

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PMID: 33408321
DOI: 10.1038/s41421-020-00223-4

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