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Biology and relevance of human acute myeloid leukemia stem cells

4 Feb 2017

Abstract excerpt

Evidence of human acute myeloid leukemia stem cells (AML LSCs) was first reported nearly 2 decades ago through the identification of rare subpopulations of engrafting cells in xenotransplantation assays. These AML LSCs were shown to reside at the apex of a cellular hierarchy that initiates and maintains the disease, exhibiting properties of self-renewal, cell cycle quiescence, and chemoresistance. This cancer...

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PMID: 28159741
DOI: 10.1182/blood-2016-10-696054

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