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Article

Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.

Nature communications - 1 Mar 2021

Velten Lars, Story Benjamin A, Hernández-Malmierca Pablo, Raffel Simon, Leonce Daniel R, Milbank Jennifer, Paulsen Malte, Demir Aykut, Szu-Tu Chelsea, Frömel Robert, Lutz Christoph, Nowak Daniel, Jann Johann-Christoph, Pabst Caroline, Boch Tobias, Hofmann Wolf-Karsten, Müller-Tidow Carsten, Trumpp Andreas, Haas Simon, Steinmetz Lars M

Abstract excerpt

Cancer stem cells drive disease progression and relapse in many types of cancer. Despite this, a thorough characterization of these cells remains elusive and with it the ability to eradicate cancer at its source. In acute myeloid leukemia (AML), leukemic stem cells (LSCs) underlie mortality but are difficult to isolate due to their low abundance and high similarity to healthy hematopoietic stem cells (HSCs)....

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Identifiers

PMID: 33649320
DOI: 10.1038/s41467-021-21650-1
PMCID: PMC7921413

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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