Article

Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

2022-08-29

Abstract excerpt

Inter-patient variability and the similarity of healthy and leukemic stem cells have impeded the characterization of leukemic stem cells (LSCs) in acute myeloid leukemia (AML), and their differentiation landscape. Here, we introduce CloneTracer, a novel method that adds clonal resolution to single-cell RNA-seq datasets. Applied to samples from 19 AML patients, CloneTracer revealed routes of leukemic differentiatio...

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Literature Corpus work: 66623e20-934b-5dae-85c2-8f6b33c65af1
DOI: 10.1101/2022.08.29.505648

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