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Single-cell Transcriptional Atlas of Human Hematopoiesis Reveals Genetic and Hierarchy-Based Determinants of Aberrant AML Differentiation

28 Apr 2025

Abstract excerpt

Therapeutic targeting of acute myeloid leukemia (AML) is hampered by intra- and inter-tumoral cell state heterogeneity. To develop a more precise understanding of AML cell states, we constructed a reference atlas of human hematopoiesis from 263,159 single-cell transcriptomes spanning 55 cellular states. Using this atlas, we mapped more than 1.2 million cells spanning 318 leukemia samples, revealing 12 recurrent...

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Acute Myeloid Leukemia Research
Single-cell and spatial transcriptomics
Zebrafish Biomedical Research Applications

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40294241
DOI: 10.1158/2643-3230.bcd-24-0342

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