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Clonally resolved single-cell multi-omics identifies routes of cellular differentiation in acute myeloid leukemia

24 Apr 2023

Abstract excerpt

Inter-patient variability and the similarity of healthy and leukemic stem cells (LSCs) have impeded the characterization of LSCs in acute myeloid leukemia (AML) and their differentiation landscape. Here, we introduce CloneTracer, a novel method that adds clonal resolution to single-cell RNA-seq datasets. Applied to samples from 19 AML patients, CloneTracer revealed routes of leukemic differentiation. Although...

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PMID: 37098346
DOI: 10.1016/j.stem.2023.04.001

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