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AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid Pathology

2026-06-16

Abstract excerpt

The inhibitory microglial receptor LILRB4 (ILT3) suppresses amyloid-beta clearance in Alzheimer’s disease (AD) through ApoE-dependent signaling but remains undrugged by small molecules. Here, we report the AI-guided discovery of small molecule inhibitors that directly disrupt the LILRB4-ApoE interaction. Ultralarge-scale screening of ∼500 million compounds identified small molecules that bind LILRB4 with nanomolar...

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Literature Corpus work: 84ee3523-6626-5c28-ab59-c95ba3eaf2ea
DOI: 10.64898/2026.06.12.731845

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