Article

The Alzheimer’s therapeutic Lecanemab induces an amyloid-clearing program in microglia

2025-07-27

Abstract excerpt

Controversies over anti-amyloid immunotherapies underscore the need to elucidate their mechanisms of action. Here we demonstrate that Lecanemab, a leading anti-Aβ antibody, mediates amyloid clearance by triggering effector functions in the microglia. Using a human microglia xenograft model, we show that Lecanemab significantly reduces Aβ pathology and associated neuritic damage, while neither Fc-inactivated Lecane...

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Literature Corpus work: cc8616ac-d240-5c2d-8c0e-674d28a7f0af
DOI: 10.1101/2025.07.24.666347

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