Article

Targeting CHI3L1 in Alzheimer’s Disease: Optimization of G721-0282 and Functional Evaluation in Astrocyte Models

2026-01-13

Abstract excerpt

Alzheimer’s disease (AD) involves astrocytic dysfunction characterized by impaired lysosomal activity, defective amyloid clearance, and neuroinflammation, processes strongly regulated by the inflammatory effector CHI3L1. G721-0282 , a reported CHI3L1-binding small molecule with demonstrated modulation of downstream signaling pathways including MAPK and STAT3, provides a validated chemical starting point for targe...

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Literature Corpus work: f188aa66-474c-5fef-9e9d-0c46ffc74213
DOI: 10.64898/2026.01.13.699206

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