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Microglial Drug Targets in AD: Opportunities and Challenges in Drug Discovery and Development

23 Aug 2019

Abstract excerpt

Alzheimer’s disease (AD) is an increasing burden to society and healthcare systems, and one of the biggest unmet medical needs with no disease-modifying treatment. Genetic evidence from genome wide association (GWAS) studies and gene network analysis have clearly revealed a key role of the innate immune system in the brain, of which microglia are the most important element. ‘Single nucleotide polymorphisms (SNPs)...

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PMID: 31507408
DOI: 10.3389/fphar.2019.00840

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