Article

PILRA regulates microglial immunometabolism to reduce disease pathology as a candidate therapeutic target for Alzheimer’s disease

2025-03-12

Abstract excerpt

<title>Abstract</title> <p> The Alzheimer’s disease (AD) genetic landscape identified microglia as a key disease-modifying cell type. A known AD protective variant in paired immunoglobulin-like type 2 receptor alpha (PILRA), shown to reduce risk in APOE4 carriers, is enriched in a cohort of healthy centenarians; however, mechanisms underlying protective effects in microglia are undefined. Here we identify biolog...

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Literature Corpus work: 02754854-4d1e-57cc-9f3b-b8ab7257148f
DOI: 10.21203/rs.3.rs-3954863/v2

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