Article

Multi-scale predictive modeling discovers Ibudilast as a polypharmacological agent to improve hippocampal-dependent spatial learning and memory and mitigate plaque and tangle pathology in a transgenic rat model of Alzheimer’s disease

2021-04-08

Abstract excerpt

Alzheimer’s disease (AD) is a multifactorial disease that exhibits cognitive deficits, neuronal loss, amyloid plaques, neurofibrillary tangles and neuroinflammation in the brain. We developed a multi-scale predictive modeling strategy that integrates machine learning with biophysics and systems pharmacology to model drug actions from molecular interactions to phenotypic responses. We predicted that ibudilast (IBU)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 13967887-7133-5559-9f41-8b8ba407d750
DOI: 10.1101/2021.04.06.438662

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-scale predictive modeling discovers Ibudilast as a polypharmacological agent to improve hippocampal-dependent spatial learning and memory and mitigate plaque and tangle pathology in a transgenic rat model of Alzheimer’s diseaseDOI 10.1101/2021.04.06.438662Read

Targeting PD-1/PD-L1-MAPK1 Signaling by a Novel Synergistic Combination of Rivastigmine and Epigallocatechin in Alzheimer’s Disease: An Integrated Insilico ApproachSemantic proximity Read

Network pharmacology-based discovery and experimental validation of novel drug repurposing candidates in Alzheimer’s DiseaseSemantic proximity Read

Integrated Bioinformatics Analysis to Identify Alternative Therapeutic Targets for Alzheimer’s Disease: Insights from a Synaptic Machinery PerspectiveSemantic proximity Read

A Map of Alzheimer’s Disease–Signaling Pathways: A Hope for Drug Target DiscoverySemantic proximity Read

Quantitative Systems Pharmacology Analysis of Amyloid Aggregation and Hippocampal Atrophy Trajectories in Alzheimer’s Disease by APOE4 Genotype and Valiltramiprosate/ALZ-801 TreatmentSemantic proximity Read

AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid PathologySemantic proximity Read

Identification and drug-induced reversion of molecular signatures of Alzheimer’s disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse modelsSemantic proximity Read

Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targetsSemantic proximity Read

From genes to network models of Alzheimer's disease: Biological framework for multi-scale brain simulation with The Virtual BrainSemantic proximity Read

Network Pharmacology-guided Identification and Molecular Validation of Multi-Target Phytoconstituents from Gmelina arborea against Alzheimer’s DiseaseSemantic proximity Read

Tailoring MAPK Pathways: New Therapeutic Avenues for Treating Alzheimer’s DiseaseSemantic proximity Read

Recent Applications of Bioinformatics in Target Identification and Drug Discovery for Alzheimer’s DiseaseSemantic proximity Read