Article

Soluble TGF-β decoy receptor TGFBR3 exacerbates AD lesions by modifying microglial function

2023-09-13

Abstract excerpt

Alzheimer’s disease (AD) is one of the major causative factors that induces progressive dementia, which is characterized by memory loss and progressive neurocognitive dysfunction. To elucidate the molecular mechanism contributing to AD, we analyzed an RNA-seq cohort of temporal cortex in AD patients using a bioinformatics workflow and demonstrated that transforming growth factor beta receptor 3 is a crucial gene r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2b30c5d2-83e6-57de-9933-cb4f9edb5480
DOI: 10.21203/rs.3.rs-3220263/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Soluble TGF-β decoy receptor TGFBR3 exacerbates AD lesions by modifying microglial functionDOI 10.21203/rs.3.rs-3220263/v1Read

Unveiling the Impact of Microglial Cells in Alzheimer's Disease Pathogenesis: Insights from Single-Cell RNA-seq Analysis and In Vivo ValidationSemantic proximity Read

Microglial Transforming Growth Factor-β Signaling in Alzheimer’s DiseaseSemantic proximity Read

Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer’s Disease: An Integrated Epigenomic-Transcriptomic AnalysisSemantic proximity Read

Immune receptor LAG3 regulates microglia function during Alzheimer’s diseaseSemantic proximity Read

Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD miceSemantic proximity Read

Soluble TREM2 induces inflammatory responses and enhances microglial survival.Semantic proximity Read

AI-Guided Discovery of Small Molecule LILRB4 (ILT3) Inhibitors Reprograms Microglia and Reduces Amyloid PathologySemantic proximity Read

Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD miceSemantic proximity Read

Disrupting microglial TGF-β signaling triggers region-specific pathology in the spinal cordSemantic proximity Read

Proliferating Microglia Exhibit Unique Transcriptional and Functional Alterations in Alzheimer’s DiseaseSemantic proximity Read

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathySemantic proximity Read

Glial cell transcriptome analyses in 3xTg-AD mice: Effects of aging, disease progression, and anti-Aβ immunotherapySemantic proximity Read