Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Microglial Lyzl4 Facilitates β‐Amyloid Clearance in Alzheimer's Disease

18 Nov 2024

Abstract excerpt

Alzheimer's Disease (AD) is a neurodegenerative condition characterized by the accumulation and deposition of amyloid-β (Aβ) aggregates in the brain. Despite a wealth of research on the toxicity of Aβ and its role in synaptic damage, the mechanisms facilitating Aβ clearance are not yet fully understood. However, microglia, the primary immune cells of the central nervous system, are known to maintain homeostasis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Immune cells in cancer
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39555667
DOI: 10.1002/advs.202412184

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Microglial Lyzl4 Facilitates β‐Amyloid Clearance in Alzheimer's DiseasePMID 39555667Read ↗

Amyloid β Induces Lipid Droplet-Mediated Microglial Dysfunction in Alzheimer’s DiseaseSemantic proximity Read ↗

Microglia in Alzheimer’s DiseaseSemantic proximity Read ↗

Unveiling the Impact of Microglial Cells in Alzheimer's Disease Pathogenesis: Insights from Single-Cell RNA-seq Analysis and In Vivo ValidationSemantic proximity Read ↗

Pathogenesis, therapeutic strategies and biomarker development based on “omics” analysis related to microglia in Alzheimer’s diseaseSemantic proximity Read ↗

A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease.Semantic proximity Read ↗

Lysosomal proteomics reveals mechanisms of neuronal apoE4-associated lysosomal dysfunctionSemantic proximity Read ↗

Unveiling microglial heterogeneity from single-cell transcriptomics in neurodegenerative diseasesSemantic proximity Read ↗

The Alzheimer’s therapeutic Lecanemab induces an amyloid-clearing program in microgliaSemantic proximity Read ↗

Microglia in Alzheimer’s disease: pathogenesis, mechanisms, and therapeutic potentialsSemantic proximity Read ↗

Age-specific activation of microglial genes in a mouse model of ADSemantic proximity Read ↗

Adhesion G protein-coupled receptor ADGRG1 promotes protective microglial response in Alzheimer’s diseaseSemantic proximity Read ↗

Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1αSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.