Article

Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases

2022-11-19

Abstract excerpt

<h4>Summary</h4> The possibility of specifying functional hematopoietic stem and progenitor cells (HSPCs) from human pluripotent stem cells (hPSCs) would overcome current limitations related to HSPC transplantation. However, generating hPSC-derived HSPCs has been elusive, necessitating a better understanding of the native developmental mechanisms that trigger HSPC specification. Here, we revealed in vivo an intr...

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Literature Corpus work: 84dbbab4-112e-5026-8ade-04f4c263c79c
DOI: 10.1101/2022.11.19.517153

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