Article

ROCK1 orchestrates B cell differentiation in response to PAMPs and heme by controlling the heme-regulated proteins Bach2 and HRI

2023-07-13

Abstract excerpt

<title>Abstract</title> <p>Protective humoral responses require that B cells successfully complete their differentiation programs even when exposed to hostile environments generated during severe infections, like the massive hemolysis triggered by malaria. The mechanisms utilized by differentiating B cells to withstand damaging conditions replete in PAMPs and DAMPs are poorly understood. Here we demonstrate that...

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Literature Corpus work: bd6c68f9-ec20-590f-964b-955b06dd1f33
DOI: 10.21203/rs.3.rs-3120870/v1

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