Article

Distinct Functional States of Neutrophils by Actin Disassembly and NF-kB/STAT3 Signaling

2023-07-17

Abstract excerpt

Polymorphonuclear neutrophils (PMNs) can differentiate into distinct states, which can either exacerbate or resolve inflammation. Our study shows that mice challenged with TLR agonists exhibited PMN differentiation along two major paths characterized by the expression of CCR5 or PD-L1. Similar differentiation was observed in the blood of severe COVID-19 patients and the synovial fluid of osteoarthritis patients. P...

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Literature Corpus work: a6b15687-01ed-5a40-825e-cbf724f30017
DOI: 10.1101/2023.07.14.548975

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