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Article

R-spondin 1 is required for specification of hematopoietic stem cells through Wnt16 and Vegfa signaling pathways.

Development (Cambridge, England) - 15 Feb 2017

Genthe Jamie R, Clements Wilson K

Abstract excerpt

Hematopoietic stem cells (HSCs) are the therapeutic component of bone marrow transplants, but finding immune-compatible donors limits treatment availability and efficacy. Recapitulation of endogenous specification during development is a promising approach to directing HSC specification in vitro, but current protocols are not capable of generating authentic HSCs with high efficiency. Across phyla, HSCs arise from...

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Identifiers

PMID: 28087636
DOI: 10.1242/dev.139956
PMCID: PMC5312032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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