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p57Kip2 regulates embryonic blood stem cells by controlling sympathoadrenal progenitor expansion

2 Jun 2022

Abstract excerpt

Hematopoietic stem cells (HSCs) are of major clinical importance, and finding methods for their in vitro generation is a prime research focus. We show here that the cell cycle inhibitor p57Kip2/Cdkn1c limits the number of emerging HSCs by restricting the size of the sympathetic nervous system (SNS) and the amount of HSC-supportive catecholamines secreted by these cells. This regulation occurs at the SNS...

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PMID: 35653588
DOI: 10.1182/blood.2021014853

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