Article

Arterial cells support the development of human hematopoietic progenitors in vitro via secretion of IGFBP2

2022-10-04

Abstract excerpt

Hematopoietic stem and progenitor cells develop from the hemogenic endothelium located in various sites during development, including the dorsal aorta from where Hematopoietic Stem Cells (HSCs) emerge. This process has proven especially challenging to recapitulate in vitro from pluripotent stem cells and further studies are needed to pinpoint the missing stimuli in vitro . Here, we compared iPSC-derived endothel...

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Literature Corpus work: 22c9dc73-c724-534c-9661-7b795e462bca
DOI: 10.1101/2022.10.04.510611

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