Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

2 May 2018

Abstract excerpt

Abstract NOTCH signaling is required for the arterial specification and formation of hematopoietic stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad-mesonephros region and extraembryonic vasculature from a distinct lineage of vascular endothelial cells with hemogenic potential. However, the role of NOTCH signaling in hemogenic endothelium (HE) specification from human pluripotent stem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Pregnancy and preeclampsia studies
Share to Renal and related cancers
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29739946
DOI: 10.1038/s41467-018-04134-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cellsPMID 29739946Read ↗

Human definitive haemogenic endothelium and arterial vascular endothelium represent distinct lineages.Semantic proximity Read ↗

A Highly Efficient Aorta-Gonad-Mesonephros-Like Definitive Hemogenic Endothelium From Human Pluripotent Stem CellsSemantic proximity Read ↗

Regulation of Hemogenic Endothelial Cell Development and FunctionSemantic proximity Read ↗

Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transitionSemantic proximity Read ↗

CD82 expression marks the endothelium to hematopoietic transition at the onset of blood specification in humanSemantic proximity Read ↗

High-Purity Production of Endothelial Cells from Human Pluripotent Stem CellsSemantic proximity Read ↗

Generating human hematopoietic stem cells <i>in vitro</i> –exploring endothelial to hematopoietic transition as a portal for stemness acquisitionSemantic proximity Read ↗

Generation and Analysis of GATA2w/eGFP Human ESCs Reveal ITGB3/CD61 as a Reliable Marker for Defining Hemogenic Endothelial Cells during Hematopoiesis.Semantic proximity Read ↗

Arterial identity of hemogenic endothelium: a key to unlock definitive hematopoietic commitment in human pluripotent stem cell culturesSemantic proximity Read ↗

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1Semantic proximity Read ↗

The genesis of human hematopoietic stem cellsSemantic proximity Read ↗

CD32 allows capturing blood cells emergence in slow motion during human embryonic developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.