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NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells

2 May 2018

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Abstract NOTCH signaling is required for the arterial specification and formation of hematopoietic stem cells (HSCs) and lympho-myeloid progenitors in the embryonic aorta-gonad-mesonephros region and extraembryonic vasculature from a distinct lineage of vascular endothelial cells with hemogenic potential. However, the role of NOTCH signaling in hemogenic endothelium (HE) specification from human pluripotent stem...

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PMID: 29739946
DOI: 10.1038/s41467-018-04134-7

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