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Nod1-dependent NF-kB activation initiates hematopoietic stem cell specification in response to small Rho GTPases

23 Nov 2023

Abstract excerpt

Uncovering the mechanisms regulating hematopoietic specification not only would overcome current limitations related to hematopoietic stem and progenitor cell (HSPC) transplantation, but also advance cellular immunotherapies. However, generating functional human induced pluripotent stem cell (hiPSC)-derived HSPCs and their derivatives has been elusive, necessitating a better understanding of the developmental...

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PMID: 37996457
DOI: 10.1038/s41467-023-43349-1

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