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RUNX1 is a key inducer of human hematopoiesis controlling non-hematopoietic mesodermal development

12 Apr 2025

Abstract excerpt

The RUNX1/AML1 transcription factor is one of the key regulators of definitive hematopoietic development in mice. However, its role in early human hematopoiesis remains poorly investigated. In this study, we integrated a tdTomato reporter cassette into the RUNX1 locus of human pluripotent stem cells (hPSCs) to monitor and block the expression of the gene during hPSC differentiation. This approach demonstrated...

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PMID: 40220285
DOI: 10.1093/stmcls/sxaf019

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